Edward F Rosloniec Selected Research

HLA-DR1 Antigen (HLA DR1 Antigen)

1/2022	CD8+ T Cells Expressing an HLA-DR1 Chimeric Antigen Receptor Target Autoimmune CD4+ T Cells in an Antigen-Specific Manner and Inhibit the Development of Autoimmune Arthritis.
1/2021	The role of posttranslational modifications in generating neo-epitopes that bind to rheumatoid arthritis-associated HLA-DR alleles and promote autoimmune T cell responses.
1/2014	Characterization of T cell phenotype and function in a double transgenic (collagen-specific TCR/HLA-DR1) humanized model of arthritis.
5/2012	Characterization of inhibitory T cells induced by an analog of type II collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis.
7/2010	An autoantigen-specific, highly restricted T cell repertoire infiltrates the arthritic joints of mice in an HLA-DR1 humanized mouse model of autoimmune arthritis.
9/2006	Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagen.
4/2005	Ex vivo characterization of the autoimmune T cell response in the HLA-DR1 mouse model of collagen-induced arthritis reveals long-term activation of type II collagen-specific cells and their presence in arthritic joints.
4/2004	Collagen-induced arthritis mediated by HLA-DR1 (0101) and HLA-DR4 (0401).
12/2002	Peptide-induced suppression of collagen-induced arthritis in HLA-DR1 transgenic mice.

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Edward F Rosloniec Research Topics

Disease

30	Arthritis (Polyarthritis) 01/2022 - 01/2002
17	Experimental Arthritis 12/2021 - 01/2002
16	Rheumatoid Arthritis 12/2021 - 01/2002
10	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 01/2002
3	Inflammation (Inflammations) 12/2021 - 07/2010
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2008 - 11/2006
1	Periodontal Diseases (Periodontal Disease) 10/2016
1	Genetic Predisposition to Disease (Genetic Predisposition) 01/2016
1	Multiple Sclerosis 11/2006

Drug/Important Bio-Agent (IBA)

18	Collagen Type II (Type II Collagen)IBA 12/2021 - 01/2002
11	Peptides (Polypeptides)IBA 01/2016 - 03/2002
9	HLA-DR1 Antigen (HLA DR1 Antigen)IBA 01/2022 - 12/2002
8	AntigensIBA 01/2022 - 03/2002
8	EpitopesIBA 01/2022 - 06/2005
7	HLA-DR Antigens (HLA-DR)IBA 01/2022 - 01/2002
6	CytokinesIBA 12/2021 - 01/2002
5	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2002
4	AntibodiesIBA 12/2021 - 06/2004
3	Freund's AdjuvantIBA 12/2021 - 01/2007
3	AutoantigensIBA 01/2021 - 11/2006
3	CollagenIBA 01/2014 - 03/2002
3	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2008 - 06/2004
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2021
2	AutoantibodiesIBA 01/2022 - 12/2003
2	Immunoglobulin G (IgG)IBA 01/2019 - 10/2017
2	HLA-DRB1 Chains (HLA DRB1)IBA 01/2018 - 12/2002
2	EnzymesIBA 10/2016 - 01/2016
2	ImmunosorbentsIBA 10/2016 - 01/2016
2	HLA-DR4 Antigen (HLA DR4 Antigen)IBA 01/2006 - 04/2004
1	Chimeric Antigen ReceptorsIBA 01/2022
1	Vitamin D FDA LinkGeneric 12/2021
1	hydroxide ionIBA 12/2021
1	20-hydroxyvitamin D3IBA 12/2021
1	Calcitriol (Calcijex)FDA LinkGeneric 12/2021
1	protein kinase DIBA 01/2019
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2019
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 01/2018
1	Anti-Citrullinated Protein AntibodiesIBA 10/2016
1	HLA Antigens (Human Leukocyte Antigens)IBA 10/2016
1	Fingolimod Hydrochloride (FTY720)FDA Link 01/2016
1	Amino Acids FDA Link 01/2016
1	Histocompatibility Antigens Class IIIBA 01/2008
1	LigandsIBA 01/2008
1	Therapeutic UsesIBA 01/2008
1	EmulsionsIBA 01/2007
1	CathepsinsIBA 11/2006
1	PeptidomimeticsIBA 11/2006
1	Peptide Hydrolases (Proteases)FDA Link 11/2006
1	Immunodominant EpitopesIBA 09/2006
1	Estrogens (Estrogen)FDA Link 12/2003
1	Estradiol (Delestrogen)FDA LinkGeneric 12/2003
1	TolerogenIBA 01/2002

Therapy/Procedure

2	Therapeutics 12/2021 - 01/2014
1	Immunotherapy 01/2022